Syphilis Blood Test (RPR with Treponemal Reflex)
$ 39.00
Syphilis Blood Test
Private, Low-Cost Syphilis Screening Test
The Syphilis Blood Test is a blood test used to screen for syphilis, a sexually transmitted infection caused by the bacteria Treponema pallidum.
This test uses a treponemal antibody assay as the initial screening step. If the initial result is reactive, it automatically reflexes to an RPR (Rapid Plasma Reagin) test. This approach is consistent with the CDC-supported reverse screening algorithm for syphilis — designed to provide more comprehensive results than a standalone RPR alone.
This test is a private, low-cost option for people who need syphilis screening for personal reasons, possible exposure, STI screening, school, work, program requirements or provider-directed testing.
✔ Treponemal antibody screening with RPR reflex
✔ Follows CDC reverse screening algorithm
✔ Private STI testing option
✔ Low-cost lab testing
✔ Useful after possible exposure or symptoms
✔ Doctor's order included
✔ No insurance required
✔ Convenient online ordering
⏱ Typical turnaround: results are usually emailed in 3–4 days.
What This Test Checks For
This test screens for syphilis using the reverse testing algorithm recommended by the CDC.
- Step 1: Treponemal antibody test (chemiluminescent immunoassay). If reactive, the test reflexes to Step 2.
- Step 2: RPR (nontreponemal test). If the RPR is positive, an RPR titer is reported. If the RPR is negative, a second treponemal antibody test (TPPA) is performed to help confirm or clarify the result.
Reflex testing is performed automatically as needed — no separate order is required.
- Test name: Syphilis: Treponemal Antibodies with Reflex to RPR and RPR Titer
- Also known as: Syphilis Blood Test, Syphilis Treponemal Test, Syphilis Reverse Screen, RPR Reflex Test, T. pallidum Screening Cascade
- LabCorp test code: 082345
- Sample type: Blood (serum)
- Methodology: Chemiluminescent immunoassay (CIA) with reflex to RPR (charcoal flocculation)
- Turnaround time: 3–4 days
- Purpose: Screens and helps diagnose syphilis infection
- Common use: STI screening, possible exposure follow-up, and provider-directed testing
Why Order a Syphilis Test?
Syphilis can be spread through sexual contact and may not always cause obvious symptoms. Some people may have symptoms that go away, even though the infection can still remain in the body.
Testing is important because untreated syphilis may cause serious health problems over time.
This test may be considered for:
- Private STI screening
- Possible syphilis exposure
- A partner who tested positive for syphilis
- Unexplained sores, rash or STI-related symptoms
- Pregnancy-related or provider-directed screening
- School, clinical, work or program-related testing requirements
- Customers who want low-cost STI testing without using insurance
How the Reverse Syphilis Algorithm Works
Unlike a standalone RPR test, this test begins with a treponemal antibody screen — which is more sensitive for detecting both early and past syphilis. The reflex cascade then provides additional clarity based on the initial result:
- Nonreactive treponemal antibody: No laboratory evidence of syphilis. If recent exposure is suspected, repeat testing in 2–4 weeks may be recommended.
- Reactive treponemal antibody + reactive RPR: Consistent with past or current syphilis. Clinical evaluation is recommended.
- Reactive treponemal antibody + nonreactive RPR + reactive TPPA: Treponemal antibodies confirmed. Consistent with past or early syphilis. Clinical evaluation is recommended.
- Reactive treponemal antibody + nonreactive RPR + nonreactive TPPA: Treponemal antibodies not confirmed. Inconclusive — may represent early syphilis or a false positive. Repeat testing may be needed.
A healthcare provider should review all results in the context of symptoms, exposure history and clinical findings.
Low-Cost Private STI Testing
This syphilis test is designed to provide a simple and affordable way to access syphilis screening.
Ordering online can help customers avoid insurance billing, reduce delays and get access to a lab order quickly.
This can be a cost-saving option for people who need discreet STI screening for personal reasons, partner notification, school, work, clinical program requirements or peace of mind.
Who May Consider This Test?
This test may be appropriate for:
- People who want private syphilis testing
- People with possible STI exposure
- People with a partner who tested positive for syphilis
- People with symptoms that may be related to syphilis
- People who need direct lab access without insurance billing
- Individuals whose healthcare provider requested syphilis or RPR testing
- People who need testing for school, work, clinical or program requirements
Common Symptoms or Reasons for Testing
Syphilis can have different stages, and symptoms may vary. Some people may not notice symptoms.
Testing may be considered if you have:
- A painless sore or ulcer in the genital, anal or mouth area
- A rash, especially on the palms or soles
- Swollen lymph nodes
- Fever, fatigue or sore throat after possible exposure
- Hair loss in patches
- A partner diagnosed with syphilis
- A need for routine or required STI screening
Important: Treponemal Antibodies May Persist
Treponemal antibodies typically remain detectable for life, even after successful treatment. A reactive treponemal antibody result does not by itself indicate active infection — it may reflect past treated syphilis.
The RPR component of this test is used to help identify active infection and may also be used by healthcare providers to monitor treatment response.
Possible False Positive Results
A reactive treponemal or RPR result does not always mean a person has syphilis.
False-positive treponemal antibody results have been observed in individuals with nonsyphilis treponemal infections (bejel, pinta, yaws). False-positive RPR results may occur with certain infections, autoimmune conditions, pregnancy, recent vaccination, injection drug use, older age or other medical factors.
This is why reactive results should always be reviewed with a licensed healthcare provider.
Important Timing Information
If exposure was recent, syphilis testing may be negative early in infection.
If recent exposure is suspected and results are negative, repeat testing in 2–4 weeks may be recommended based on your healthcare provider's guidance.
Important Health Warning
If you have genital sores, rectal sores, mouth sores, rash, fever, eye pain, vision changes, severe headache, confusion, hearing changes, pregnancy-related concerns, symptoms after sexual assault or any urgent medical concern, seek medical care promptly.
Do not use this test as a substitute for urgent medical evaluation, diagnosis or treatment.
Screening and Lab Access Only
LabReqs and SchoolTiters provide access to lab testing. We do not diagnose syphilis, prescribe antibiotics, provide STI treatment or manage partner notification.
If your result is reactive or abnormal, you should contact a licensed healthcare provider promptly for interpretation, confirmatory testing if needed and treatment guidance.
Important Limitations
- This test screens for syphilis using treponemal antibody testing with reflex to RPR.
- Treponemal antibodies may persist for life after treatment and cannot be used alone to confirm active infection.
- This test does not include HIV, chlamydia, gonorrhea, hepatitis or herpes unless ordered separately.
- A nonreactive result does not always rule out very recent syphilis exposure.
- False-positive treponemal or RPR results can occur.
- This test does not determine the stage of syphilis by itself.
- This test does not provide antibiotic treatment.
Before Ordering
- Order this test if you need syphilis screening.
- If you need a full STI panel, consider ordering additional STI tests.
- If you have symptoms, contact a healthcare provider before or after testing.
- If exposure was recent, repeat testing may be needed later.
- If your result is reactive, abnormal or unclear, review it with a licensed healthcare provider.
- If you test positive, sex partners may also need testing and treatment.
How It Works
- Order online.
- Receive your lab order. A doctor's order is included.
- Visit a participating lab location.
- Provide a blood sample.
- Receive your results. Review reactive, abnormal or unclear results with a healthcare provider.
Why Choose This Syphilis Test?
✅ Treponemal + RPR reflex testing — more comprehensive than standalone RPR
✅ Follows CDC-supported reverse syphilis screening algorithm
✅ Private syphilis STI screening
✅ Low-cost testing option
✅ No insurance required
✅ Doctor's order included
✅ Convenient online ordering
✅ Results can be shared with your healthcare provider
Frequently Asked Questions
What does this Syphilis Blood Test check for?
This test screens for syphilis using a treponemal antibody assay. If reactive, it automatically reflexes to RPR testing (and if needed, a confirmatory TPPA) following the CDC reverse screening algorithm.
How is this different from a standard RPR test?
A standard RPR test only checks for nontreponemal antibodies. This test begins with a treponemal antibody screen, which is more sensitive for early and past syphilis, and uses the RPR as a reflex step — consistent with current CDC guidance.
Is this a private STI test?
Yes. This test allows you to order online and access lab testing without using insurance.
Is this a low-cost syphilis test?
Yes. This product is designed to provide a low-cost option for syphilis screening.
What does a reactive treponemal antibody result mean?
A reactive treponemal result means treponemal antibodies were detected. This may reflect current infection, past treated infection or, rarely, a false positive. The RPR reflex and clinical evaluation help clarify the result.
What does a reactive RPR mean?
A reactive RPR means nontreponemal antibodies were detected. Combined with a reactive treponemal result, this is consistent with past or current syphilis. A healthcare provider should evaluate the result.
What does a nonreactive result mean?
A nonreactive treponemal result means no laboratory evidence of syphilis was found. If exposure was recent, repeat testing in 2–4 weeks may be recommended.
Does this test include treatment?
No. This product provides lab testing access only. Treatment decisions must be made by a licensed healthcare provider.
Should partners be tested?
If syphilis is suspected or confirmed, sex partners may need testing and treatment. A healthcare provider or local health department can help guide next steps.
Is a doctor's order included?
Yes. A doctor's order is included with this lab test.
Order Your Syphilis Blood Test
Use this low-cost, private test when you need convenient access to syphilis screening without using insurance.
Order your Syphilis Blood Test today.
Syphilis Blood Test (RPR with Treponemal Reflex)
$ 39.00
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